Calcitrol 0.25mcg

Calcitriol 0.25mcg Soft Gel Capsule

Calcitrol 0.5mcg

Calcitriol 0.5mcg Soft Gel Capsule

Calcitrol 1mcg/ml

Calcitriol 1mcg/ml Injection

Features
Benefits
Indications & Dosage

Features:

Calciwin (calcitriol) is the active form of vitamin D3 (cholecalciferol). The natural or endogenous supply of vitamin D in man mainly depends on ultraviolet light for conversion of 7-dehydrocholesterol to vitamin D3 in the skin. Vitamin D3 must be metabolically activated in the liver and the kidney before it is fully active on its target tissues.

Benefits:

The known sites of action of Calciwin (calcitriol) are intestine, bone, kidney and parathyroid gland. Calciwin (calcitriol) is the most active known form of vitamin D3 in stimulating intestinal calcium transport. Calciwin (calcitriol) has been shown to stimulate intestinal calcium absorption. In bone, calcitriol, in conjunction with parathyroid hormone, stimulates resorption of calcium; and in the kidney, calcitriol increases the tubular reabsorption of calcium. Calciwin (calcitriol) directly suppresses secretion and synthesis of PTH. A vitamin D-resistant state may exist in uremic patients because of the failure of the kidney to adequately convert precursors to the active compound, calcitriol.

Indications & Dosage:

The dosage should be adjusted carefully for each patient according to serum calcium concentration.

Renal Osteodystrophy

  • Initial dose: 0.25 mcg/day.
  • If normal or slightly reduced serum calcium levels, 0.5 mcg/day may be sufficient.
  • If no improvement, increase by 0.25 mcg/day every 2-4 weeks.
  • Monitor serum calcium at least weekly.
  • Maintenance dose: 0.5-1 mcg/day.
  • Higher doses may be required for hyperparathyroidism, with adequate calcium intake (800-1000 mg/day).

Osteoporosis

  • Recommended dose: 0.25 mcg twice daily.
  • If response is inadequate, increase by 0.5 mcg twice daily at one-month intervals.
  • Monitor serum calcium at least weekly.

Hypoparathyroidism and Rickets

  • Recommended dose: 0.25 mcg/day in the morning.
  • If no response, increase every 2-4 weeks.
  • Monitor serum calcium at least weekly.
  • Higher doses may be required for hypoparathyroidism.